ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2026
Carboplatin/Paclitaxel can be an effective alternative for cisplatin-ineligible patients with locally advanced HNSCC.
Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDespite considerable therapeutic advances, a significant evidence gap remains regarding optimal treatment strategies for cisplatin-unfit patients and whether carboplatin/paclitaxel represents a valid therapeutic alternative. This study investigates the treatment outcomes of patients receiving various platinum-based chemotherapy regimens.
methodsBetween 2012 and 2022, 170 patients with LAHNSCC were included in the analysis. Overall survival (OS) and progression-free survival (PFS), as well as treatment-related toxicities, were evaluated.
resultsThe included patients were treated with intensity-modulated radiotherapy (IMRT) at a total dose of 59.4-72 Gy, along with 5-6 cycles of weekly platinum-based chemotherapy. 130 patients received cisplatin (40 mg/m
conclusionDefinitive and postoperative radiochemotherapy for the treatment of LAHNSCC with concurrent administration of carboplatin/paclitaxel can be used as a safe and effective alternative but only for cisplatin-ineligible patients.
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