ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Nickel-Catalyzed Three-Component Difluoroalkylation-Amination for the Direct Access to Anti-Inflammatory β-Difluoroalkyl Amines.
Chang Xu, Fangting Ma, Fan Ding, Luyan Wang, Yunxi Li, Yunzhi He, Xingang Zhang, Siyu He, Dandan Liu
Abstract read
In one paragraphArticle in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Chang XuSchool of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan, People's Republic of China.ORCID https://orcid.org/0000-0002-2942-6094 Fangting MaSchool of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan, People's Republic of China.
Fan DingSchool of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan, People's Republic of China.
Luyan WangSchool of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan, People's Republic of China.
Yunxi LiSchool of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan, People's Republic of China.
Yunzhi HeSchool of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan, People's Republic of China.
Xingang ZhangState Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0002-4406-6533 Siyu HeSchool of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan, People's Republic of China.
Dandan LiuSchool of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan, People's Republic of China.ORCID https://orcid.org/0000-0002-0880-9686 Funding
First-Class Discipline Team of Kunming Medical University 2024XKTDTS12Innovation Team of Yunnan Provincial Department of EducationNational Natural Science Foundation of China 22101104National Natural Science Foundation of China 22467015National Natural Science Foundation of China 82560704Yunnan Fundamental Research Projects 202501CF070022Yunnan Revitalization Talent Support ProgramYunnan Talent Support Plan 202605AS350023Yunnan Xingdian Talent Support Program YNWR-QNBJ-2020-276
6 · The paper itselfAbstract
Fluoroalkyl amines represent a promising structural motif in pharmaceutical sciences, but the development of an efficient and practical synthetic method is in urgent need, especially for β-difluoroalkyl amines, in which the concurrent introduction of fluoroalkyl and aminyl groups remains challenging. Here, we report a nickel-catalyzed three-component reductive difluoroalkylation-amination strategy of enamides for the direct access to the α-amidyl-β-difluoroalkyl amines. This strategy utilizes carboamination of alkene with nitrogen electrophiles and fluoroalkyl chlorides to simultaneously forge C─C and C(sp
Indexed as
anti‐inflammationcarboaminationin vitro and in vivo studynickel catalysisSH2‐type reactionβ‐difluoroalkyl amines
Identifiers
PMID42545098
PMCPMC13430932
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