Evidence map›Paper›PMID 42544585›Full record

ArticleThe Journal of clinical investigation2026

LINGO1-targeted antibody-drug conjugates improve efficacy and tolerability of antineoplastic therapies in Ewing sarcoma models.

Zhichuan Zhu, Yusha Liu, Yu Deng, Zhijun Li, Albert S Baldwin, Pengda Liu

Abstract read
In one paragraph

Article in The Journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhichuan ZhuLineberger Comprehensive Cancer Center.
Yusha LiuLineberger Comprehensive Cancer Center.
Yu DengLineberger Comprehensive Cancer Center.
Zhijun LiLineberger Comprehensive Cancer Center.
Albert S BaldwinLineberger Comprehensive Cancer Center.
Pengda LiuLineberger Comprehensive Cancer Center.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We reported LINGO1 as a potential marker on Ewing sarcoma cells that could enable targeted drug delivery, improving treatment effectiveness while reducing side effects.

Indexed as

Antineoplastic AgentsBone NeoplasmsImmunoconjugatesMembrane ProteinsNeoplasm ProteinsNerve Tissue ProteinsSarcoma, EwingAnimalsCell Line, TumorHumansMiceAntineoplastic AgentsImmunoconjugatesMembrane ProteinsNeoplasm ProteinsNerve Tissue ProteinsBone diseaseCancerCell biologyOncologyTherapeutics

Identifiers

PMID42544585
PMCPMC13430015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.