ArticleJournal of veterinary internal medicine2026
Retrospective evaluation of C-reactive protein for discriminating between lower urinary tract infections and acute pyelonephritis in dogs.
Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
backgroundThe role of C-reactive protein (CRP) in differentiating pyelonephritis from other types of urinary tract infection in dogs is not well defined. HYPOTHESIS/
objectivesCompare serum CRP concentrations at diagnosis in dogs with acute pyelonephritis (APy), acute prostatitis (APr), and bacterial cystitis (BC). Serum CRP concentration is hypothesized to be higher in APy and APr than in BC. ANIMALS: One hundred fifteen client-owned dogs were included: 56 with BC, 32 with APy, 23 with APr, and 4 with both APy and APr.
methodsRetrospective observational study. Dogs with positive urine culture were included and divided into 3 groups (BC, APy, and APr), based on medical history. Dogs with comorbidities potentially affecting CRP concentrations and dogs with subclinical bacteriuria were excluded. Data were compared among groups, and the diagnostic accuracy of CRP was assessed post-hoc.
resultsDogs with BC had lower median CRP (1.04 mg/dL; range, 0.08-7.21) than those with APy (23.65 ± 11.96 mg/dL; median difference [MD], 22.9 mg/dL; 95% CI, 18.2-26.5; P < .001) and APr (20.9 mg/dL; range, 5.93-55.97; MD, 19.9 mg/dL; 95% CI, 10.7-25.6; P < .001), whereas APy and APr did not differ (MD, -3.0 mg/dL; 95% CI, -10.6 to 4.4; P > .99). Serum CRP concentration had high discriminative ability to differentiate dogs with BC and APy, APr, or both (area under the curve [AUC], 0.99; 95% CI, 0.99-1). CONCLUSIONS AND CLINICAL IMPORTANCE: Serum CRP concentration evaluated at diagnosis, when highly increased, may help differentiate BC from APy in dogs without concurrent inflammatory diseases.
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