ArticleInfectious diseases & clinical microbiology2026
Epidemiological and Laboratory Evaluation of Central Nervous System Infections Using the BioFire FilmArray Meningitis/Encephalitis Panel in a Tertiary Care Hospital in İstanbul.
Article in Infectious diseases & clinical microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Rapid and accurate identification of central nervous system (CNS) pathogens is essential for appropriate antimicrobial management. This study aimed to evaluate the performance of the BioFire FilmArray Meningitis/Encephalitis (ME) Panel compared with conventional cerebrospinal fluid (CSF) analysis. Materials and Methods: This retrospective study was conducted at a tertiary care hospital over a three-year period. Cerebrospinal fluid samples were analyzed using routine microbiological methods (culture and Gram staining), cytological examination, biochemical testing, and multiplex PCR with the BioFire FilmArray ME Panel. Results: A total of 1470 CSF samples were analyzed, and pathogens were detected in 104 samples (7.1%), including 57 viral pathogens, 39 bacterial pathogens, one fungal pathogen, and six co-infections. Culture positivity was observed in one case each of Conclusion: The BioFire FilmArray ME Panel, when interpreted in conjunction with routine CSF biochemical and cytological parameters, provides a rapid and reliable diagnostic approach for differentiating bacterial from viral CNS infections. Graphical Abstract: Graphical Abstract.
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