ArticleFrontiers in neurology
Association of nadir serum albumin during hospitalization with mortality in ICU patients with spontaneous intracerebral hemorrhage.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Hypoalbuminemia is common among critically ill patients and has been associated with adverse clinical outcomes. However, the prognostic significance of the nadir serum albumin level during hospitalization in patients with spontaneous intracerebral hemorrhage (ICH) admitted to the intensive care unit (ICU) remains unclear. This study aimed to investigate the association between in-hospital lowest serum albumin levels and clinical outcomes in ICU patients with spontaneous ICH. Methods: We conducted a retrospective cohort study using pooled data from the Tianjin cohort and Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Adult ICU patients with spontaneous ICH were included. The primary outcome was 28-day all-cause mortality. Multivariable Cox proportional hazards models were used to assess associations between nadir serum albumin during ICU stay and 28-day mortality. Restricted cubic splines (RCS) were applied to examine potential nonlinear relationships. Results: The incidence of 28-day mortality increased from 17.2% in the >35 g/L group to 39.3% in the < 30 g/L group, while 90-day mortality increased from 21.2% to 52.0% (both Conclusion: Lower nadir serum albumin levels during hospitalization are independently associated with increased mortality in ICU patients with spontaneous ICH. The prognostic value of albumin appears to vary by illness severity and treatment intensity, as reflected by MV status. These findings suggest that nadir serum albumin level may be a simple and clinically relevant prognostic marker for risk stratification in this population.
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