Evidence map›Paper›PMID 42543895›Full record

ArticleMuscle & nerve2026

Lumbosacral Plexopathy: A Single-Center Review of Etiology, Clinical Presentation, Electrodiagnostic Findings, and Long-Term Outcomes.

Bradley Ong, Jad El Ahdab, Nicolas Thompson, Yuebing Li, Nirmal Andrapalliyal

Abstract read
In one paragraph

Article in Muscle & nerve, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Bradley OngDepartment of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0001-6507-1967
Jad El AhdabDepartment of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-6793-417X
Nicolas ThompsonDepartment of Quantitative Health Sciences, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-8973-5219
Yuebing LiDepartment of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-4248-8927
Nirmal AndrapalliyalDepartment of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID https://orcid.org/0009-0001-8686-3098

Funding

American Academy of NeurologyAmerican Headache Society
6 · The paper itself

Abstract

INTRODUCTION/

aimsLumbosacral plexopathy (LSP) results from a spectrum of etiologies and can cause substantial functional impairment. Limited data exist on the relative distribution of etiologies and outcomes across broad tertiary-care cohorts spanning multiple causes of LSP. This study aimed to describe the etiologic distribution and characterize the clinical, electrodiagnostic (EDx), and outcome features of LSP.

methodsWe retrospectively reviewed records of patients diagnosed with LSP at our center from January 2000 to September 2024. Definite LSP was defined by a clinical and electrodiagnostic pattern localizing predominantly to the lumbosacral plexus, with supportive sensory and/or imaging findings. Probable LSP met similar clinical and EDx criteria but lacked sufficient sensory or imaging confirmation.

resultsOf 1139 screened records, 124 patients met criteria for LSP (38 definite [30.6%], 86 probable [69.4%]). Median age was 64 years (IQR 54-72), and 59 (47.6%) were female. Symptom onset was acute in 47 (37.9%), subacute in 9 (7.3%), and chronic in 68 (54.8%). Sensorimotor symptoms predominated (71.0%). Leading etiologies included diabetic lumbosacral radiculoplexus neuropathy (34.7%), perioperative injury (25.8%), idiopathic LSP (14.5%), radiation-induced plexopathy (12.1%), and autoimmune LSP (6.5%). Among 85 patients with follow-up, 35 (41.2%) achieved full or near-complete recovery. DISCUSSION: These findings are consistent with prior descriptions of LSP and radiculoplexus neuropathy and emphasize the heterogeneity of etiologies seen in tertiary care. Recovery was often incomplete, supporting the need for careful diagnostic evaluation and realistic counseling regarding outcome.

Indexed as

Lumbosacral PlexusPeripheral Nervous System DiseasesAgedElectrodiagnosisFemaleHumansMaleMiddle AgedNerve Conduction StudiesRetrospective Studiesdiabetic lumbosacral radiculoplexus neuropathyelectrodiagnostic studiesetiologylumbosacral plexopathyplexopathy

Identifiers

PMID42543895
PMCPMC13549159

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.