ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026
Ferroptosis-Based Peripheral Immune Dysregulation and Diagnostic Signatures in Parkinson's Disease: An RNA Transcriptomic and Single-Cell Immune Sequencing Analysis.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Parkinson's disease (PD) is a common neurodegenerative disorder in which ferroptosis and immune dysregulation have been implicated. However, the crosstalk between ferroptosis-related transcriptional signatures and peripheral immune alterations in PD remain unclear. Herein, we integrated bulk transcriptomic datasets and a peripheral blood single-cell dataset to identify ferroptosis-related genes associated with PD and to evaluate their diagnostic potential. Initially, we identified 16 abnormally expressed ferroptosis-related genes (AEFRGs) associated with peripheral immune cell infiltration in PD. Then a LASSO-derived 15-gene signature was established, which showed high discriminatory performance in the discovery dataset and in two validation datasets, including an independent blood dataset and a substantia nigra dataset. Consensus clustering of PD samples based on 276 ferroptosis-related genes (FRGs) stratified PD patients into three molecular subtypes with different diagnostic scores, immune scores, immune-related factors, and cell-death/oxidative-stress pathway enrichment. The imumue cell infiltration analysis indicated low level of macrophage and high level of B cell in PD patients' perioheral blood. Peripheral blood single-cell analysis localized ferroptosis-related transcriptional features mainly related to NK cells, CD4
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