ArticleKorean journal of radiology2026
Retroareolar Intraductal Lesions Detected by Screening Ultrasound in Dense Breasts: Malignancy Rate and Predictive Imaging Features.
Article in Korean journal of radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe clinical significance of intraductal lesions detected as primary findings on screening breast ultrasound (US) remains unclear. This study aimed to determine the malignancy rate of retroareolar intraductal lesions detected by supplemental screening breast US in asymptomatic women with mammographically dense breasts and to identify imaging features associated with malignancy. MATERIALS AND
methodsThis multicenter retrospective study included asymptomatic women with dense breasts who had intraductal lesions located in the retroareolar area detected on screening breast US between January 2012 and December 2021. Sonographic and mammographic features were evaluated by three radiologists. Logistic regression analysis was conducted to identify imaging and clinicopathologic factors associated with malignancy. The diagnostic performance of imaging features for predicting malignant retroareolar intraductal lesions was assessed. A reader study was performed to evaluate interreader agreement for sonographic features.
resultsAmong 550 intraductal lesions in 544 women (mean age ± standard deviation, 49.8 ± 9.3 years), 529 (96.2%) were benign, and 21 (3.8%) were malignant. Multivariable analysis demonstrated that a beyond-the-duct appearance (adjusted odds ratio [OR], 11.4; 95% confidence interval [CI], 2.4-53.3;
conclusionRetroareolar intraductal lesions detected on screening US in women with dense breasts exhibited a low malignancy rate of 3.8%. A beyond-the-duct appearance and the presence of vascularity on color Doppler US were independently associated with malignancy in retroareolar intraductal lesions detected on screening breast US.
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