ArticleInternal medicine (Tokyo, Japan)2026
Scleroderma Renal Crisis and Posterior Reversible Encephalopathy Syndrome Triggered by Non-steroidal Anti-inflammatory Drugs.
Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Scleroderma renal crisis (SRC) and posterior reversible encephalopathy syndrome (PRES) are rare but severe complications of systemic sclerosis (SSc). We report the case of a 44-year-old patient with SSc who developed SRC and PRES, potentially triggered by non-steroidal anti-inflammatory drugs (NSAIDs). The patient presented with impaired consciousness, renal dysfunction, hemolytic anemia, thrombocytopenia, and occipital white matter lesions on magnetic resonance imaging. Treatment included enalapril, hemodialysis, and plasma exchange. This case highlights the potential role of NSAIDs in the development of SRC, and emphasizes the importance of considering NSAIDs as a significant risk factor for SRC in patients with SSc.
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