ArticleGeroScience2026
Understanding temporal changes in intrinsic capacity: analysis of domain-specific intrinsic capacity using SHARE data.
Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Global population aging challenges acute, disease-centric healthcare models and highlights the need for functional markers of aging. The World Health Organization's intrinsic capacity (IC) framework, encompassing cognition, vitality, locomotion, psychological well-being, and sensory function, provides a multidimensional measure of functional reserve. However, most longitudinal studies have collapsed IC into a single score, limiting insight into domain-specific trajectories and interrelationships. In this longitudinal cohort study, we examined 7-year changes in composite and domain-specific IC scores, stratified by age and sex, and assessed associations between changes across domains among community-dwelling adults aged 50 years and older participating in the Survey of Health, Ageing and Retirement in Europe (SHARE). The analytic sample included 27,107 participants (56.5% women; mean age 65.1 ± 8.2 years) with complete IC data at baseline (Wave 6, 2015) and follow-up (Wave 9, 2022). IC was operationalized as a 0-50 composite score derived from five domains, each standardized to a 0-10 scale using SHARE-specific measures. Over 7 years, composite IC declined statistically significantly (mean difference - 1.57 points; 95% CI - 1.63 to - 1.50; p < 0.001), with greater decline in men than women (- 1.71 vs - 1.46; p < 0.001). Locomotion domain contributed most to overall decline across age groups. Changes in vitality were moderately correlated with changes in locomotion (r≈0.30) and psychological well-being (r≈0.25), suggesting that vitality may function as a physiological node linking physical and psychological domains. These findings demonstrate that IC declines progressively from midlife, with steeper trajectories in men, and support domain-specific monitoring to better characterize age-related functional decline.
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