Evidence map›Paper›PMID 42542877›Full record

ArticleJournal of cell communication and signaling2026

The suppressor of cytokine signaling 3 regulates glioma stem cell maintenance and immune microenvironment through signal transducer and activator of transcription 3 signaling.

Jingtao Wang, Gaolei Hou, Zhaofei Song, Kai Gao, Hongbin Wang, Tao Li

Abstract read
In one paragraph

Article in Journal of cell communication and signaling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jingtao WangThe Fourth Department of Neurosurgery Affiliated Hospital of Hebei Engineering University Handan China.
Gaolei HouThe Fourth Department of Neurosurgery Affiliated Hospital of Hebei Engineering University Handan China.ORCID https://orcid.org/0000-0002-2556-0261
Zhaofei SongThe Fourth Department of Neurosurgery Affiliated Hospital of Hebei Engineering University Handan China.
Kai GaoThe Fourth Department of Neurosurgery Affiliated Hospital of Hebei Engineering University Handan China.
Hongbin WangThe Fourth Department of Neurosurgery Affiliated Hospital of Hebei Engineering University Handan China.
Tao LiThe Fourth Department of Neurosurgery Affiliated Hospital of Hebei Engineering University Handan China.ORCID https://orcid.org/0009-0007-6814-3197

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to elucidate the role of suppressor of cytokine signaling 3 (SOCS3) in glioma stem cells (GSCs) via single-cell RNA sequencing (scRNA-seq), focusing on its regulation of STAT3-mediated self-renewal, apoptosis resistance, and tumor microenvironment (TME) remodeling. ScRNA-seq data from 19 high-grade glioma patients were analyzed using Seurat, Harmony, and SingleR for clustering, annotation, and SOCS3 stratification (SOCS3-High:

Indexed as

apoptosis resistanceglioma stem cellsscRNA‐seqSOCS3STAT3 signalingtumor microenvironment

Identifiers

PMID42542877
PMCPMC13428608

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.