Evidence map›Paper›PMID 42542816›Full record

ArticleCureus2026

A Master of Disguise: Disseminated Fungal Disease Revealing Immunodeficiency.

Rajashekar V, Akshaya Kumar B, Hema K, Senthil Priyan K, Mukil S, Anitha A, Venisha M, Sahasyaa Adalarasan, Rachana R, Santhi Ts

Abstract readCase Reports
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rajashekar VInternal Medicine, Madras Medical College, Chennai, IND.
Akshaya Kumar BInternal Medicine, Madras Medical College, Chennai, IND.
Hema KInternal Medicine, Madras Medical College, Chennai, IND.
Senthil Priyan KInternal Medicine, Madras Medical College, Chennai, IND.
Mukil SInternal Medicine, Madras Medical College, Chennai, IND.
Anitha AInternal Medicine, Madras Medical College, Chennai, IND.
Venisha MMedicine, Madras Medical College, Chennai, IND.
Sahasyaa AdalarasanMedicine, Madras Medical College, Chennai, IND.
Rachana RInternal Medicine, Madras Medical College, Chennai, IND.
Santhi TsInternal Medicine, Madras Medical College, Chennai, IND.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disseminated fungal infection (DFI) is the presence of a fungal pathogen in the blood and/or any other deep-seated site due to vascular spread. It represents a rare but life-threatening infectious complication in immunocompromised patients. In this case report, we present a 19-year-old male with weakness of the limbs, headache, and slurred speech. He was a known case of endobronchial fungal infection with worsening neurological symptoms. Motor examination revealed reduced tone and strength, while respiratory examination revealed bilaterally decreased air entry. Fundoscopic examination revealed papilledema. Immunological evaluation demonstrated elevated IgE and IgG levels and a reduced CD16/56 natural killer cell count, indicating defective innate immunity. Radiological examination, including computed tomography (CT), positron emission tomography-computed tomography (PET-CT), and magnetic resonance imaging (MRI), demonstrated nodules with opacities and mediastinal and cervical lymphadenopathy in the chest, as well as multiple supratentorial and infratentorial lesions, extensive edema, and nodular leptomeningeal thickening on neuroimaging. The patient is hypothesized to have dysfunctional ryanodine receptors (RyR) rather than typical CGD. The patient was managed with antifungal therapy along with antiepileptic and antiedema drugs.

Indexed as

calcium signaling defectcerebral fungal infectionchronic granulomatous diseasechronic granulomatous disease mimicdisseminated fungal diseaseendobronchial fungal infectionoxidative burst defectphagocytic dysfunctionryanodine receptor defect

Identifiers

PMID42542816
PMCPMC13428554

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.