Evidence map›Paper›PMID 42542738›Full record

ArticleSudanese journal of paediatrics2026

Serum zinc response to standard therapy in acute versus persistent pediatric diarrhea: a prospective comparative study.

Mohammad Irfan, Shrish Bhatnagar, Shalini Verma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sudanese journal of paediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mohammad IrfanDepartment of Pediatrics, Era's Lucknow Medical College and Hospital, Lucknow, India.
Shrish BhatnagarDepartment of Pediatrics, Era's Lucknow Medical College and Hospital, Lucknow, India.
Shalini VermaDepartment of Pediatrics, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zinc supplementation is recommended in both acute and persistent diarrhea; however, comparative data on longitudinal biochemical response between these conditions are limited. This prospective observational study was conducted at the pediatric department of a tertiary care center in Northern India, which enrolled 72 children: 36 with acute diarrhea (group A) and 36 with persistent diarrhea (group B). All participants received oral zinc sulfate syrup providing 20 mg elemental zinc daily for 14 days. Serum zinc was measured at Day 1, 14, and 28. Longitudinal analysis was performed using a linear mixed-effects model with time and group as fixed effects and subject as a random effect. A gradual increase in serum zinc was observed in both groups. No statistically significant group-time interaction was detected, indicating similar trajectories. Zinc supplementation resulted in a modest but consistent increase in serum zinc levels in both groups. No significant difference was detected between acute and persistent diarrhea. These findings do not suggest a need for higher dosing; however, further adequately powered studies are warranted.

Indexed as

Acute diarrheaPediatric diarrheaPersistent diarrheaSerum zinc levelsZinc supplementation

Identifiers

PMID42542738
PMCPMC13427771

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.