A Comparative Study of the Effects of Allantoin and Metformin on Blood Sugar Levels and Body Weight in Streptozotocin-Induced Diabetic Wistar Rats.

Prathmesh R Gargate, Chitra Khanwelkar, Vandana M Thorat, Sujata Jadhav, Anjali Shinde, Kaushalendra Mani

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Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Prathmesh R GargateDepartment of Pharmacology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.

Chitra KhanwelkarDepartment of Pharmacology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.

Vandana M ThoratDepartment of Pharmacology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.

Sujata JadhavDepartment of Pharmacology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.

Anjali ShindeDepartment of Pharmacology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.

Kaushalendra ManiDepartment of Pharmacology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction Diabetes is among the many known chronic diseases resulting from the inability of the body to produce insulin. The use of traditional drugs such as sulfonylurea, biguanide, and thiazolidinediones has been associated with some side effects, hence making researchers turn their attention toward herbal medicine as a treatment or prevention option for diabetes. Hence, the present study was designed to evaluate and compare the metabolic effects of allantoin (5 mg/kg and 10 mg/kg), metformin (500 mg/kg), and their combination on blood glucose and body weight in low-dose streptozotocin (STZ)-induced diabetic Wistar rats. Methods An in vivo study employed a randomized, controlled, parallel-group, preclinical experimental design consisting of a total of 36 young adult (8-10 weeks old) male Wistar rats (

Indexed as

allantoinbody weightdiabetes mellitusfasting blood sugarfbsherbal remediesmetforminstreptozotocint2dmtype 2 diabetes mellitus

Identifiers

PMID42542595

DOI10.7759/cureus.111923

PMCPMC13427629

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