Evidence map›Paper›PMID 42542516›Full record

ArticleOphthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)2026

Influence of Refractive Index of the Crystalline Lens on Optical Biometric Measurements.

Ji C He

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Article in Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

1 author.

Ji C HeNew England College of Optometry, Boston, Massachusetts, USA. hej@neco.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study was to model the effects of variation in the refractive index of the crystalline lens on theoretical biometric measurements.

methodsMeasurement errors of the axial length of the eye (AL) and lens thickness (LT) were modelled while the lens refractive index and related ocular segment sizes were varied from a 30-year-old model eye. Two approaches of optical path-length (OPL) conversion, the weighted mean ocular refractive index (WMORI) and the segmented refractive index (SRI), were specifically examined.

resultsIn the WMORI approach, when lens refractive index, LT and vitreous chamber depth (VCD) were varied together, AL measurement was either underestimated by 0.209 mm or overestimated by 0.390 mm. The VCD was a major influencing factor. In the SRI approach, the AL measurement error was reduced to 0.077 mm. The same amount of LT measurement error was also found as in the AL.

conclusionThe SRI approach provides an improvement over the WMORI in AL measurement because the influence of the VCD was eliminated. Use of a model eye parameter for OPL conversion always causes biometric measurement errors in individual eyes due to the variations in lens refractive index. The newly developed in vivo measurement of lens refractive index needs to be applied in optical biometry to improve AL and LT measurements for individual eyes in the areas of myopia research and cataract surgery.

Indexed as

Axial Length, EyeBiometryLens, CrystallineRefraction, OcularAdultHumansRefractometryAxial lengthCrystalline lensIndividual variationLens thicknessOptical biometryRefractive index

Identifiers

PMID42542516

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.