Evidence map›Paper›PMID 42542506›Full record

ArticleEye (London, England)2026

Perforating scleral vessel angular metrics as a structural biomarker of myopic choroidal neovascularisation.

Alberto Quarta, Alessandro Feo, Francesco Romano, Giulia Corradetti, Federico Corvi, Mai Alhelaly, Rouzbeh Abbasgholizadeh, Shinichiro Chujo, Marko Popovic, Ceren Soylu and 6 more

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Article in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

16 authors.

Alberto QuartaDoheny Eye Institute, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-0818-6124
Alessandro FeoDepartment of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0009-0005-2999-6782
Francesco RomanoEye Clinic, Department of Biomedical and Clinical Science "Luigi Sacco", Sacco Hospital, University of Milan, Milan, Italy.
Giulia CorradettiDoheny Eye Institute, Pasadena, CA, USA.
Federico CorviEye Clinic, Department of Biomedical and Clinical Science "Luigi Sacco", Sacco Hospital, University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0002-2661-5500
Mai AlhelalyDoheny Eye Institute, Pasadena, CA, USA.ORCID http://orcid.org/0000-0003-0574-1660
Rouzbeh AbbasgholizadehDoheny Eye Institute, Pasadena, CA, USA.
Shinichiro ChujoDoheny Eye Institute, Pasadena, CA, USA.
Marko PopovicDoheny Eye Institute, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-0370-5968
Ceren SoyluDoheny Eye Institute, Pasadena, CA, USA.
Yu-Chien ChungDoheny Eye Institute, Pasadena, CA, USA.ORCID http://orcid.org/0000-0003-4745-8601
Hyun Duck KwakDoheny Eye Institute, Pasadena, CA, USA.
Jianfeng HuangDoheny Eye Institute, Pasadena, CA, USA.
Muneeswar G NittalaDoheny Eye Institute, Pasadena, CA, USA.
Giovanni StaurenghiEye Clinic, Department of Biomedical and Clinical Science "Luigi Sacco", Sacco Hospital, University of Milan, Milan, Italy.
Srinivas R SaddaDoheny Eye Institute, Pasadena, CA, USA. ssadda@doheny.org.ORCID http://orcid.org/0000-0002-4939-3306

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo quantitatively assess the entrance angle variability and location of perforating scleral vessels (PSVs) in highly myopic eyes and to investigate its association with myopic choroidal neovascularisation (mCNV) versus lacquer cracks (LC).

methodsEntrance angles from the sclera to choroid were measured on each B-scan OCT using ImageJ and associated angle metrics were calculated per PSVs. Additional variables included subfoveal choroidal thickness (SFCT) and vessel-to-fovea distance (VFD). In mCNV eyes the total number of injections and treatment duration were also accounted.

resultsA total of 42 eyes were included, 25 with mCNV and 17 with LC. Eyes with mCNV demonstrated significantly greater PSV angular variability including angular standard deviation, and their normalised metrics compared to LC eyes (all p < 0.001). VFD was shorter in the mCNV group (50.2 ± 52.6 µm vs. 91.5 ± 39.6 µm, p = 0.006). Normalised angle metrics correlated positively with the total number of anti-VEGF injections (r ≈ 0.37, p < 0.05), whereas no association was observed with treatment duration. In multivariable regression, no predictors reached statistical significance although normalised angle range (NAR) showed a trend toward a negative association with VFD (p = 0.060).

conclusionsPSV angular variability was markedly greater in mCNV eyes and correlated with anti-VEGF injection burden reflecting higher treatment intensity but not longer disease duration. These findings suggest that PSV geometry influences LC and mCNV, may serve as an imaging biomarker of disease activity in mCNV. Shorter VFD and greater angular dispersion likely reflect structural and hemodynamic alterations predisposing to mCNV.

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PMID42542506

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