Evidence map›Paper›PMID 42542437›Full record

ArticleOncogene2026

Oncogene SETDB1's dual role: driving tumor progression and immune escape.

Kiarash Salari, Jiaqing Hao, Ryan Jilek, Matthew Wells, Tianyue Li, Eleanor Johnson, Wendy Meng, Huiyaxin Wang, Ethan Zibble, Adam Allen and 12 more

Abstract read
In one paragraph

Article in Oncogene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Kiarash SalariDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa, IA, USA.ORCID http://orcid.org/0000-0003-2528-1315
Jiaqing HaoDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa, IA, USA.
Ryan JilekDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa, IA, USA.ORCID http://orcid.org/0009-0002-5194-1073
Matthew WellsDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa, IA, USA.
Tianyue LiDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa, IA, USA.
Eleanor JohnsonDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa, IA, USA.ORCID http://orcid.org/0000-0001-9231-4768
Wendy MengDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa, IA, USA.
Huiyaxin WangDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa, IA, USA.ORCID http://orcid.org/0009-0000-1787-9857
Ethan ZibbleDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa, IA, USA.
Adam AllenDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa, IA, USA.
Jack GilbertDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa, IA, USA.
Ryan McLerranDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa, IA, USA.
Emma SchuettDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa, IA, USA.
Claudia OlivaDepartment of Radiation Oncology, University of Iowa, Iowa, IA, USA.
Corinne E GriguerDepartment of Radiation Oncology, University of Iowa, Iowa, IA, USA.
David K MeyerholzDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa, IA, USA.ORCID http://orcid.org/0000-0003-1552-3253
Melinda S YatesDepartment of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-9450-5517
Henry L KeenIowa Institute of Human Genetics, Carver College of Medicine, University of Iowa, Iowa, IA, USA.
Xiangbing MengDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa, IA, USA.
Yiqin XiongDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa, IA, USA.
Bing LiDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa, IA, USA.
Shujie YangDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa, IA, USA. shujie-yang@uiowa.edu.ORCID http://orcid.org/0000-0003-1753-3068

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Jon C.D. Houtman · 2000 to 2026
$70.0M
Determine the role of SETDB1 in controlling lipid metabolism in obesity-associated cancerU01CA272424 · NCI · UNIVERSITY OF IOWA · PI Bing Li · 2022 to 2026
$6.0M
Restoring Progestin Sensitivity in Endometrial CancerR37CA238274 · NCI · UNIVERSITY OF IOWA · PI YANG, SHUJIE · 2019 to 2025
$2.4M
NCI NIH HHS P30 CA086862NCI NIH HHS R37 CA238274NCI NIH HHS U01 CA272424U.S. Department of Health & Human Services | National Institutes of Health (NIH) U01CA272424U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) P30CA086862U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R37CA238274U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) U01CA272424
6 · The paper itself

Abstract

Oncogene SETDB1, an H3K9 methyltransferase, drives tumorigenesis in various cancers. Using endometrial cancer (EC) as a model, we discovered SETDB1's dual mechanisms in driving EC tumorigenesis and mediating immune evasion. SETDB1 knockout (SETDB1

Indexed as

Histone-Lysine N-MethyltransferaseTumor EscapeAnimalsCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMacrophagesMiceMice, KnockoutOncogenesHistone-Lysine N-MethyltransferaseSETDB1 protein, humanSETDB1 protein, mouse

Identifiers

PMID42542437
PMCPMC13549952

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.