Evidence map›Paper›PMID 42541594›Full record

ArticleEuropean journal of nutrition2026

RNA methylation and the potential role of folate supplementation in preventing Hirschsprung disease.

Chunxia Du, Jie Tang, Zhengke Zhi, Hongxing Li, Weibing Tang

Abstract read
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In one paragraph

Article in European journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chunxia DuDepartment of Neonatal Surgery, Children's Hospital of Nanjing Medical University, 72 Guangzhou Road, Nanjing, 210008, China.
Jie TangDepartment of Neonatal Surgery, Children's Hospital of Nanjing Medical University, 72 Guangzhou Road, Nanjing, 210008, China.
Zhengke ZhiDepartment of Neonatal Surgery, Children's Hospital of Nanjing Medical University, 72 Guangzhou Road, Nanjing, 210008, China.
Hongxing LiDepartment of Neonatal Surgery, Children's Hospital of Nanjing Medical University, 72 Guangzhou Road, Nanjing, 210008, China.
Weibing TangDepartment of Neonatal Surgery, Children's Hospital of Nanjing Medical University, 72 Guangzhou Road, Nanjing, 210008, China. twbcn@njmu.edu.cn.

Funding

Natural Science Foundation of China 81801496Natural Science Foundation of China 81900460
6 · The paper itself

Abstract

purposeTo determine whether folate supplementation may reduce the incidence of Hirschsprung disease (HSCR) by regulating the methylation level of growth arrest-specific 5 (GAS5).

methodsThe m6A methylation deficiency model and folate supplementation model were created using the m

resultsSupplementation of folate can ameliorate the decreased ENCSC proliferation ability caused by low m

conclusionAdditional folate supplementation during early embryonic development may serve as a strategy for preventing HSCR.

Indexed as

Dietary SupplementsFolic AcidHirschsprung DiseaseRNA MethylationAnimalsCell ProliferationDisease Models, AnimalFemaleHumansMaleMiceZebrafishFolic AcidEnteric nervous systemFolateHSCRm6A methylation

Identifiers

PMID42541594

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.