ArticleEuropean journal of clinical pharmacology2026
Association between venetoclax concentration and febrile neutropenia in acute leukemia: a retrospective analysis.
Article in European journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeVenetoclax, a selective BCL-2 inhibitor, demonstrates efficacy in acute leukemia (AL) but variable pharmacokinetics. Therapeutic drug monitoring (TDM) may provide valuable pharmacologic insights for optimizing venetoclax therapy. This study explored the factors influencing plasma venetoclax concentrations and their correlation with febrile neutropenia (FN), aiming to establish predictive thresholds.
methodsAL patients receiving venetoclax between August 2023 and March 2025 were retrospectively analyzed. Plasma concentration, baseline characteristics, pharmacogenomics, and clinical parameters were collected. Univariate and multivariate linear regression analyses were performed to identify determinants of venetoclax concentrations and factors associated with FN incidence. Receiver operating characteristic (ROC) curves were used to define FN-predictive thresholds.
resultsThe cohort comprised 123 patients, with FN developing in 35 cases (28.5%). The median trough concentration (C
conclusionHigher venetoclax concentrations increase FN risk. Regular monitoring of blood venetoclax concentration using TDM may help identify patients at increased FN risk. The determination of this concentration threshold can provide a basis for optimizing the treatment quality of AL patients.
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