Evidence map›Paper›PMID 42541572›Full record

ArticleSurgery today2026

Early drain fluid lymphocyte fraction as a predictor of postoperative infectious complications after hepatectomy.

Kenei Furukawa, Masashi Tsunematsu, Koichiro Haruki, Yoshihiro Shirai, Michinori Matsumoto, Shinji Onda, Munetoshi Akaoka, Tomohiko Taniai, Mitsuru Yanagaki, Toru Ikegami

Abstract read
PubMed Publisher
In one paragraph

Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kenei FurukawaDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan. k-furukawa@jikei.ac.jp.
Masashi TsunematsuDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Koichiro HarukiDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Yoshihiro ShiraiDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Michinori MatsumotoDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Shinji OndaDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Munetoshi AkaokaDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Tomohiko TaniaiDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Mitsuru YanagakiDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Toru IkegamiDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePostoperative infectious complications remain one of the most common morbidities after hepatectomy. We conducted this study to evaluate whether the lymphocyte fraction in drain fluid could serve as a surrogate marker of postoperative infectious complications after hepatectomy.

methodsThe subjects of this retrospective analysis were 265 patients who underwent hepatectomy. Drain fluid samples were collected on postoperative day (POD) 1, for biochemical and hematologic evaluation. The associations between the lymphocyte fraction in drain fluid and postoperative infectious complications were examined using univariate and multivariate logistic regression analyses.

resultsPostoperative infectious complications developed in 43 patients (16%). Multivariate analysis identified biliary reconstruction (odds ratio (OR) 4.20, p = 0.02), total bilirubin concentration in drain fluid ≥ 1.0 mg/dL (OR 3.32, p < 0.01), and lymphocyte fraction in drain fluid < 0.7% (OR 4.09, p < 0.01) as independent risk factors. No correlation was found between peripheral blood and drain fluid lymphocyte fractions (r = 0.02, p = 0.77).

conclusionA reduced lymphocyte fraction in drain fluid on POD1 is an independent predictor of postoperative infectious complications after hepatectomy and may reflect the postoperative local immune environment rather than systemic immunity.

Indexed as

DrainHepatectomyLymphocyteSurgical site infection

Identifiers

PMID42541572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.