Evidence map›Paper›PMID 42541571›Full record

ArticleSurgery today2026

Pancreaticoduodenectomy is associated with more progressive bone mineral density loss than distal pancreatectomy.

Shunta Ishizaki, Masashi Tsunematsu, Kenei Furukawa, Tomohiko Taniai, Yuto Yamahata, Koichiro Haruki, Yoshihiro Shirai, Michinori Matsumoto, Shinji Onda, Toru Ikegami

Abstract read
PubMed Publisher
In one paragraph

Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shunta IshizakiDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato- ku, Tokyo, 105-8461, Japan.
Masashi TsunematsuDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato- ku, Tokyo, 105-8461, Japan. tsunematsu@jikei.ac.jp.
Kenei FurukawaDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato- ku, Tokyo, 105-8461, Japan.
Tomohiko TaniaiDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato- ku, Tokyo, 105-8461, Japan.
Yuto YamahataDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato- ku, Tokyo, 105-8461, Japan.
Koichiro HarukiDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato- ku, Tokyo, 105-8461, Japan.
Yoshihiro ShiraiDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato- ku, Tokyo, 105-8461, Japan.
Michinori MatsumotoDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato- ku, Tokyo, 105-8461, Japan.
Shinji OndaDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato- ku, Tokyo, 105-8461, Japan.
Toru IkegamiDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato- ku, Tokyo, 105-8461, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePancreatic resection can lead to the malabsorption of nutrients for bone metabolism. This study compared longitudinal changes in bone mineral density (BMD) between patients who underwent pancreaticoduodenectomy (PD) and those who underwent distal pancreatectomy (DP).

methodsThe subjects of this retrospective analysis were 153 patients who underwent pancreatic resection, as PD in 102 and as DP in 51, between July, 2017 and November, 2022, and survived for at least 3 years. BMD was measured in Hounsfield units (HU) at the 11th thoracic vertebra on routine CT imaging. Risk factors for significant BMD loss (ΔBMD > 20 HU) and longitudinal changes were evaluated.

resultsThe cumulative incidence of fractures 2, 4, and 6 years after pancreatic resection was 2.6%, 7.9%, and 13.5%, respectively. Multivariate analysis identified preoperative BMD > 103 HU (p = 0.001) and PD (p < 0.001) as independent risk factors for ΔBMD > 20 HU. Linear mixed-effects analysis demonstrated a greater decline in BMD after PD than after DP (p for interaction < 0.001), whereas no significant differences were observed in serum albumin levels or body weight. ΔBMD > 20 HU was significantly associated with a higher fracture incidence (p = 0.020).

conclusionPD is associated with a greater postoperative BMD loss than DP, highlighting the importance of proactive monitoring and interventions targeting bone metabolism.

Indexed as

Bone mineral densityFractureOsteopeniaPancreaticoduodenectomy

Identifiers

PMID42541571

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.