Evidence map›Paper›PMID 42541553›Full record

ReviewAbdominal radiology (New York)2026

The bulging pancreas: unmasking causes beyond autoimmunity-an imaging-based approach to diffuse pancreatic enlargement.

Julia Espíndola Guimarães, Thiago Nogueira Fachini, Levi Brito Siebra de Oliveira, Nicole Dittrich, Matheus Menezes Gomes, Ulysses S Torres, Eduardo Oliveira Pacheco, Aley Talans, Daniella Braz Parente, Giuseppe D'Ippolito

Abstract readReview
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In one paragraph

Review in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julia Espíndola GuimarãesDepartment of Radiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil. juliaespindolaguimaraes@gmail.com.
Thiago Nogueira FachiniRadiology Institute (InRad), Universidade de São Paulo, São Paulo, Brazil.
Levi Brito Siebra de OliveiraDepartment of Radiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Nicole DittrichDepartment of Radiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Matheus Menezes GomesDepartment of Radiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Ulysses S TorresDepartment of Radiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil. ulysses.torres@grupofleury.com.br.
Eduardo Oliveira PachecoDepartment of Radiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil. pachecoeduardodr@gmail.com.
Aley TalansRadiology Institute (InRad), Universidade de São Paulo, São Paulo, Brazil.
Daniella Braz ParenteDepartment of Radiology, Fleury S.A. (Brazil), São Paulo, Brazil.
Giuseppe D'IppolitoDepartment of Radiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil. giuseppe_dr@uol.com.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diffuse pancreatic enlargement is frequently attributed to autoimmune pancreatitis (AIP), but several benign, genetic, inflammatory, including acute interstitial edematous pancreatitis, and malignant entities can produce a similar imaging appearance. This review provides an imaging-based approach to recognize diffuse pancreatic enlargement, apply pragmatic measurement rules, and differentiate AIP from key mimics. Classic AIP imaging features (diffuse "sausage-like" morphology, capsule-like rim, long-segment duct narrowing without marked upstream dilation) and the value of clinical/serologic correlation and steroid response are emphasized. Key mimics reviewed include acute interstitial edematous pancreatitis, pancreatic lipomatosis, von Hippel-Lindau (VHL) disease, Mahvash syndrome, infiltrative adenocarcinoma, lymphoma, metastases, and diffuse neuroendocrine tumor, each with discriminating imaging and clinical clues. A structured assessment combining objective measurement, duct evaluation, enhancement pattern, systemic findings, and response to therapy after pancreatic malignancy has been reasonably excluded can reduce misdiagnosis of diffuse pancreatic enlargement and expedite appropriate biopsy or oncologic workup when indicated.

Indexed as

Acute interstitial edematous pancreatitisAutoimmune pancreatitisDiffuse pancreatic enlargementLymphomaMahvash syndromeMetastasesNeuroendocrine tumorPancreatic cancer mimicsPancreatic lipomatosisVon Hippel-Lindau

Identifiers

PMID42541553

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.