ArticleMolecular carcinogenesis2026
Cancer-Associated Fibroblast-Derived FGF7 Promotes Immune Escape in Oral Squamous Cell Carcinoma via JAK/STAT3-Mediated PD-L1 Expression.
Article in Molecular carcinogenesis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Cancer-Associated Fibroblast-Derived FGF7 Promotes Immune Escape in Oral Squamous Cell Carcinoma via JAK/STAT3-Mediated PD-L1 Expression.Molecular carcinogenesis · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
Oral squamous cell carcinoma (OSCC) exhibits high recurrence rates, and immune escape within the tumor microenvironment is a critical barrier to effective therapy. This study investigates whether cancer-associated fibroblast (CAF)-derived FGF7 promotes immune escape in OSCC through JAK/STAT3 pathway-mediated PD-L1. Tumor and adjacent tissues from OSCC patients were analyzed for FGFF7 expression, and the correlations between FGF7 and clinicopathological features were analyzed. CAFs were isolated from OSCC, transfected with plasmids targeting FGF7, and assessed for activation markers, 3D spheroid formation, and epithelial-mesenchymal transition (EMT) proteins. Co-culture systems were established to evaluate the malignant behaviors of OSCC cells exposed to modified CAFs through proliferation, migration, invasion, and apoptosis assays. OSCC cells were co-cultured with CD8
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