Evidence map›Paper›PMID 42541426›Full record

ArticleArchives of insect biochemistry and physiology2026

Neuroprotective Potential of Spermidine in Drosophila sws Neurodegenerative Model.

Anastasiia Raspopina, Marta Tkachuk, Nataliya Matiytsiv

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of insect biochemistry and physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anastasiia RaspopinaDepartment of Genetics and Biotechnology, Ivan Franko National University of Lviv, Lviv, Ukraine.ORCID https://orcid.org/0000-0003-3012-0268
Marta TkachukDepartment of Genetics and Biotechnology, Ivan Franko National University of Lviv, Lviv, Ukraine.ORCID https://orcid.org/0009-0008-9318-4086
Nataliya MatiytsivDepartment of Genetics and Biotechnology, Ivan Franko National University of Lviv, Lviv, Ukraine.ORCID https://orcid.org/0000-0002-1582-2037

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative disorders are characterized by progressive neuronal loss and functional decline, yet effective interventions remain limited. The polyamine spermidine was suggested to exert neuroprotective effects, but its concentration-dependent impact on longevity, neuronal integrity, and behavior remains still not well studied. Here, we investigated the effects of spermidine on lifespan, behavioral responses, brain tissue, target gene expression, and antioxidant status in Drosophila melanogaster model of age-dependent neurodegeneration. Wild-type flies and swiss cheese (sws

Indexed as

Drosophila melanogasterDrosophila ProteinsNeurodegenerative DiseasesNeuroprotective AgentsSpermidineAnimalsAntioxidantsBrainDisease Models, AnimalLongevityMutationNerve Tissue ProteinsOxidative StressAntioxidantsDrosophila ProteinsNerve Tissue ProteinsNeuroprotective AgentsSpermidineSWS protein, Drosophilaage‐related diseasesantioxidantDrosophilagene swiss cheeseneuroprotectionoxidative stressSpermidine

Identifiers

PMID42541426
PMCPMC13428469

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.