ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026
NLRC5-Deficient Macrophages Promote a Tumor-Permissive Phenotype via AXL- and MERTK-Mediated Efferocytosis.
Shambel Araya Haile, Alessandra Gatta, Nina Colon, Dana J Philpott, Thomas A Kufer, Le Ying, Dongmei Tong, Richard L Ferrero
Abstract read
In one paragraphArticle in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Shambel Araya HaileCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Alessandra GattaCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Nina ColonCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Dana J PhilpottDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.
Thomas A KuferDepartment of Immunology, Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.
Le YingCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Dongmei TongCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Funding
DHAC | National Health and Medical Research Council (NHMRC) APP1079904DHAC | National Health and Medical Research Council (NHMRC) APP1107930DHAC | National Health and Medical Research Council (NHMRC) APP2012620EC | Erasmus+ (Еразъм+)German Academic Exchange Service (DAAD)MU | Faculty of Medicine, Nursing and Health Sciences, Monash University (FMNHS)Public Health Agency of Canada (PHAC)State Government of Victoria (VicGovAu)Tour de Cure (TDC) RSP-330-2020U.S. Department of Defense (DOD) W81XWH-17-1-0606
6 · The paper itselfAbstract
The innate immune protein NLRC5 plays a key role in cancer immune surveillance. Reduced NLRC5 expression is associated with a poor prognosis for many types of cancers. Previously, we showed that mice with a myeloid-specific deletion of Nlrc5 (Nlrc5
Indexed as
c-Mer Tyrosine KinaseIntracellular Signaling Peptides and ProteinsMacrophagesProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesAnimalsAxl Receptor Tyrosine KinaseBenzocycloheptenesEfferocytosisHelicobacter InfectionsHumansMiceMice, Inbred C57BLMice, KnockoutPhenotypeTriazolesAxl Receptor Tyrosine KinaseAXL receptor tyrosine kinase, mousebemcentinibBenzocycloheptenesc-Mer Tyrosine KinaseIntracellular Signaling Peptides and ProteinsMertk protein, mouseNLRC5 protein, mouseProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesTriazolesefferocytosisgastric B‐cell lymphomaHelicobacter pyloriNLRC5tumor‐associated macrophages
Identifiers
PMID42541333
PMCPMC13428295
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