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ArticleOpen respiratory archives

The P4COPD Study: Rationale, Goals and Study Design - Prediction, Prevention, Personalized and Precision Management of COPD in Young Adults.

Àlvar Agustí, Xènia Carrizosa-Guerri, Ciro Casanova, Borja Cosio, Fatima Crispi, Alberto Fernández-Villar, Judith Garcia-Aymerich, Luis González-de Paz, Juan R Gonzalez, Amanda Iglesias and 16 more

Abstract read
In one paragraph

Article in Open respiratory archives. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Àlvar AgustíPulmonary Department, Respiratory Institute, Clinic Barcelona, Spain.
Xènia Carrizosa-GuerriUniversity of Barcelona, Barcelona, Spain.
Ciro CasanovaDepartment of Pulmonology/Research Unit, Nuestra Señora de Candelaria University Hospital, Universidad de La Laguna, Tenerife, Spain.
Borja CosioCentro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Barcelona, Spain.
Fatima CrispiUniversity of Barcelona, Barcelona, Spain.
Alberto Fernández-VillarCentro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Barcelona, Spain.
Judith Garcia-AymerichISGlobal, Barcelona, Spain.
Luis González-de PazFundació Clínic per la Recerca Biomèdica (FCRB) - Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Juan R GonzalezBioinformatic Research Group in Epidemiology (BRGE), Barcelona Institute for Global Health (ISGlobal), 08003 Barcelona, Spain.
Amanda IglesiasHealth Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Spain.
Jose Luis IzquierdoUniversity of Alcalá, Madrid, Spain.
Marta Marin-OtoPulmonary Department, Hospital Universitario Miguel Servet, University of Zaragoza, Zaragoza, Spain.
Jose Maria MarinPulmonary Department, Hospital Universitario Miguel Servet, University of Zaragoza, Zaragoza, Spain.
Rommy NovoaUniversity of Barcelona, Barcelona, Spain.
Andrea OcañaFundació Clínic per la Recerca Biomèdica (FCRB) - Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Sergi PascualHospital del Mar, Barcelona, Spain.
Gabriela PeraltaISGlobal, Barcelona, Spain.
Lídia PereaFundació Clínic per la Recerca Biomèdica (FCRB) - Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
David Sanz-RubioPrecision Medicine in Respiratory Diseases, Instituto Investigación Sanitaria de Aragón, Zaragoza, Spain.
David Sarrat-GonzalezBioinformatic Research Group in Epidemiology (BRGE), Barcelona Institute for Global Health (ISGlobal), 08003 Barcelona, Spain.
Maties TorrentHealth Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Spain.
Miguel VazquezBarcelona Supercomputing Center (BSC) - National Supercomputing Center, Barcelona, Spain.
Valle VelascoPediatric Pulmonology, Canary Islands University Hospital, Tenerife, Spain.
Marc VilaUniversity of Barcelona, Barcelona, Spain.
Rosa FanerUniversity of Barcelona, Barcelona, Spain.
P4COPD Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) is a major public health problem. Research over the past few years has shown that COPD is the result of dynamic and cumulative gene-environment interactions starting early in life. This opens new opportunities for the Prediction, Prevention, Personalized and Precise management (P4) of COPD in Materials and methods: The P4COPD study leverages from already existing cohorts (EarlyCOPD, INMA, LEVANTE, Aduheart) of young subjects (18-50 years) and Results: First results are expected in the third and fourth quarters of 2026. Conclusions: Identifying

Indexed as

Chronic bronchitisEmphysemaPre-COPD

Identifiers

PMID42541279
PMCPMC13427418

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.