ReviewGenes & diseases2026
Lipophagy: A key regulator in oxidative stress and metabolic disorders.
Review in Genes & diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Modulation of Obesity-Related Lipid Metabolism by Sulforaphane Through AMPK-Centered Molecular Networks.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipophagy, the selective autophagic degradation of lipid droplets, is essential for regulating cellular lipid levels and energy balance while preventing lipotoxicity. This process integrates with metabolic pathways, particularly in counteracting oxidative stress by clearing excess lipids that generate reactive oxygen species. Dysregulation of lipophagy contributes to metabolic disorders, including obesity and diabetes, where impaired lipid clearance leads to insulin resistance, inflammation, and tissue damage. It also exerts protective effects in cardiovascular health by modulating lipid accumulation in atherosclerosis and influences neurodegenerative diseases by alleviating lipid-induced neuronal stress. This review emphasizes the therapeutic potential of targeting lipophagy, proposing that pathway modulation could offer innovative strategies for treating lipid dysregulation-associated diseases. Advancing knowledge of lipophagy's mechanisms and its interplay with oxidative stress may enable therapies that tackle underlying pathologies beyond symptom management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.