ArticleiScience2026
Regulatory role of IRF2 in proliferation and invasion of nasopharyngeal carcinoma and its underlying mechanism.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
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Abstract
IRF2 is an interferon regulatory factor with context-dependent roles in cancer. We examined IRF2 expression and function in nasopharyngeal carcinoma (NPC) using immunohistochemistry, immunofluorescence, western blot, and functional assays in cell lines and a xenograft model. IRF2 was upregulated and predominantly nuclear in NPC, correlating with advanced T stage and higher EBV DNA load. ROC analysis indicated diagnostic value (AUC = 0.837). IRF2 overexpression promoted proliferation, migration, invasion, epithelial-mesenchymal transition (EMT) and suppressed apoptosis, whereas knockdown inhibited these phenotypes and reduced tumor growth
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