Evidence map›Paper›PMID 42541146›Full record

ArticleExploration (Beijing, China)2026

Quadruplex Bioactive FAND for Treating Acute Liver Failure Induced by Acetaminophen or Hepatectomy.

Meng Sun, Fang Fang, Juan Liu, Yueyun Fan, Sa Wang, Chuang Zhang, Weiyu Li, Zhengyang Quan, Dongxu Zhao, Min Hu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Exploration (Beijing, China), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Meng SunKey Laboratory of Molecular Medicine and Biotherapy School of Life Sciences Beijing Institute of Technology Beijing P. R. China.
Fang FangKey Laboratory of Molecular Medicine and Biotherapy School of Life Sciences Beijing Institute of Technology Beijing P. R. China.ORCID https://orcid.org/0009-0005-2092-8644
Juan LiuHepato-Pancreato-Biliary Center Key Laboratory of Digital Intelligence Hepatology (Ministry of Education) Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University Beijing P. R. China.
Yueyun FanKey Laboratory of Molecular Medicine and Biotherapy School of Life Sciences Beijing Institute of Technology Beijing P. R. China.
Sa WangKey Laboratory of Molecular Medicine and Biotherapy School of Life Sciences Beijing Institute of Technology Beijing P. R. China.
Chuang ZhangKey Laboratory of Molecular Medicine and Biotherapy School of Life Sciences Beijing Institute of Technology Beijing P. R. China.
Weiyu LiKey Laboratory of Molecular Medicine and Biotherapy School of Life Sciences Beijing Institute of Technology Beijing P. R. China.
Zhengyang QuanKey Laboratory of Molecular Medicine and Biotherapy School of Life Sciences Beijing Institute of Technology Beijing P. R. China.
Dongxu ZhaoKey Laboratory of Molecular Medicine and Biotherapy School of Life Sciences Beijing Institute of Technology Beijing P. R. China.
Min HuDepartment of Hepatobiliary Surgery Jinan University First Affiliated Hospital Guangzhou P. R. China.ORCID https://orcid.org/0000-0003-0222-4326
Jinfeng ZhangKey Laboratory of Molecular Medicine and Biotherapy School of Life Sciences Beijing Institute of Technology Beijing P. R. China.ORCID https://orcid.org/0000-0002-1899-888X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute liver failure (ALF), characterized by severe hepatocyte necrosis with a high mortality rate, remains a major global health challenge. However, there are currently no effective drug options for the clinical treatment of ALF. Herein, inspired by the new concept of a full-API nanodrug (FAND), we have rationally developed a quadruplex bioactive FAND (termed FAND

Indexed as

acute liver failure (ALF)anti‐inflammationfull‐API nanodrug (FAND)fusion extracellular vesicleshepatectomy

Identifiers

PMID42541146
PMCPMC13426876

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.