Evidence map›Paper›PMID 42540638›Full record

ArticleiScience2026

Dose-response framework for DSS-induced colitis in mice.

Siyan Che, Jinglong Peng, Xia Xu, Yue Wang, Mujie Huang, Lin Zhao, Bin Feng, Pan Huang, Jianjun Li, Miaomiao Wu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Siyan CheInstitute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China.
Jinglong PengAnimal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Yuelushan Laboratory, Changsha, Hunan 410128, China.
Xia XuHunan Provincial Key Laboratory of Forestry Biotechnology, Central South University of Forestry and Technology, Changsha 410004, China.
Yue WangAnimal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Yuelushan Laboratory, Changsha, Hunan 410128, China.
Mujie HuangAnimal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Yuelushan Laboratory, Changsha, Hunan 410128, China.
Lin ZhaoAnimal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Yuelushan Laboratory, Changsha, Hunan 410128, China.
Bin FengAnimal Disease-resistant Nutrition, Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Pan HuangInstitute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China.
Jianjun LiInstitute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China.
Miaomiao WuAnimal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Yuelushan Laboratory, Changsha, Hunan 410128, China.
Yulong YinInstitute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dextran sulfate sodium (DSS) is widely used to model epithelial injury-driven colitis, but heterogeneous dosing complicates model selection and cross-study comparison. Here, we established a graded DSS dose-response framework by administering 0%, 1.5%, 2.0%, 2.5%, or 3.0% DSS to C57BL/6J mice for 5 days, followed by 2 days of recovery, and integrated pathological, microbial, transcriptomic, and immune profiling. Low-dose DSS (1.5%-2.0%) induced mild and largely reversible epithelial injury, early microbiota perturbation, and CD8

Indexed as

dextran sulfate sodiumdose-dependent colitismicrobiota dysbiosismucosal immune activation

Identifiers

PMID42540638
PMCPMC13426225

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.