ArticleNeuro-oncology advances
Chromosomal instability is associated with paradoxical cGAS upregulation and impaired STING signaling shaping the immune microenvironment in glioblastoma.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Glioblastoma (GBM) is characterized by pronounced chromosomal instability (CIN), which can activate the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway and promote anti-tumor immunity. How CIN engages cGAS-STING in immunologically "cold" GBM and its relation to clinical outcomes remain unclear. Methods: CIN was quantified in 74 tissue cores from 34 patients with isocitrate dehydrogenase-wildtype GBM by chromosome 7/10 fluorescence Results: High AS (≥1.36) was associated with longer overall survival (22.7 vs. 16.0 months, Conclusions: CIN was associated with cGAS upregulation but not functional STING-mediated immunity in GBM, suggesting that CIN-associated intrinsic stress adaptation may contribute to immunotherapy resistance in GBM.
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