ArticleArchives of medical science : AMS2026
The association between frailty and headache in middle-aged and older individuals: a data analysis based on the GBD2021, the CHARLS and Mendelian randomization.
Article in Archives of medical science : AMS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Headache is a common neurological disease with a significant impact on individuals and a high social economic burden. Material and methods: We explored the association between frailty (assessed by FI) and incidence of new headaches among older individuals using the Global Burden of Disease database and the China Health and Retirement Longitudinal Study (CHARLS). Results: We examined 2108 individuals aged 60 years and older, and found that 16.56% of them reported incidence headache. The results demonstrated a clear association between higher levels of frailty and higher risks of headaches. Higher FI was associated with 1% higher odds of having headaches (OR = 1.12, Conclusions: The growing global burden of headaches, especially in older adults, underscores the urgency of targeted interventions. Our findings imply that frailty may be a potential indicator of headache risk, and they call for healthcare strategies to reduce the incidence of headache by intervening in frailty. In the future, we will focus on the biological processes underlying the frailty-headache association to provide credible targets for personalized treatment and evidence-based preventive care.
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