Evidence map›Paper›PMID 42540500›Full record

ReviewCureus2026

Psychosis in the Age of Large Language Models (LLMs): A Narrative Review of the Proposed Construct of AI-Induced Psychosis.

Terry X Tong, Zoe Z Gong, Sharon Y Yao

Abstract readReview
In one paragraph

Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Terry X TongDepartment of Psychological and Behavioural Science, London School of Economics and Political Science, London, GBR.
Zoe Z GongDepartment of Psychology, Concordia International School Shanghai, Shanghai, CHN.
Sharon Y YaoDepartment of Applied Psychology and Human Development, University of Toronto, Toronto, CAN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapid integration of AI chatbots powered by large language models (LLMs) into daily life has been accompanied by reports of psychosis-like presentations following intensive human-AI interaction, a phenomenon we provisionally label AI-induced psychosis as a working construct rather than a validated clinical entity. This hypothesis-generating narrative review synthesizes case reports from media accounts, court documents, and a recently published case compilation, together with theoretical frameworks from clinical psychiatry, cognitive science, and human-computer interaction, to propose a conceptual model for further empirical investigation. We hypothesize that AI-induced psychosis arises through a human-AI delusional feedback loop, in which AI sycophancy may amplify emotional vulnerabilities, such as loneliness, anxiety, and depression, creating a self-reinforcing cycle that could co-construct and consolidate delusional beliefs. Drawing on distributed cognition theory and the Computers Are Social Actors (CASA) paradigm, we propose that AI chatbots may function as both a complementary cognitive tool and a relational "Quasi-Other," providing sycophantic verification that may transform delusional beliefs into an apparent shared reality. Four recurring delusional themes are tentatively identified from reported cases. We further compare AI-induced psychosis with schizophrenia, while acknowledging that several distinctions remain hypothesized rather than empirically established. The label AI-induced psychosis is used phenomenologically, not to assert causal certainty; whether AI chatbots cause, precipitate, reinforce, or merely organize the thematic content of pre-existing psychopathology requires longitudinal study. This review aims to lay conceptual groundwork for clinical recognition and to guide future empirical investigation into whether AI-induced psychosis represents a distinct phenomenon or a variant of established disorders.

Indexed as

ai chatbotsai-induced psychosisai sycophancydelusionshuman-ai delusional feedback looplarge language modelsschizophrenia

Identifiers

PMID42540500
PMCPMC13425832

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.