ArticleCureus2026
C-Reactive Protein as a Predictor of Early Antibiotic Treatment Failure in Hospitalized Patients With Community-Acquired Pneumonia.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
backgroundCommunity-acquired pneumonia (CAP) is one of the leading causes of hospitalization and infectious mortality worldwide. Identifying factors associated with early response to antibiotic treatment may improve clinical outcomes.
methodsThis retrospective, analytical, observational study included 230 adult patients hospitalized with CAP at Regional General Hospital No. 1 of the Mexican Social Security Institute in Chihuahua, Mexico, between June 2024 and December 2025. Clinical variables, comorbidities, inflammatory biomarkers, and severity scores were evaluated. Statistical analysis included chi-square tests and binary logistic regression.
resultsA total of 230/230 (100%) patients were included. The mean age was 63.9 ± 12.7 years, and 121/230 (52.6%) patients were male and 109/230 (47.4%) were female. A favorable response to the initial antibiotic regimen was observed in 143/230 (62.2%) patients, whereas 87/230 (37.8%) required therapeutic escalation. Mortality was higher among patients requiring escalation than those who did not (31/87 (35.6%) vs. 18/143 (12.6%), χ²=15.8, df=1, p<0.001, Cramér's V=0.26). In multivariable analysis, higher baseline C-reactive protein (CRP) levels were independently associated with non-response to initial antibiotic therapy (OR=1.98; 95% CI: 1.10-3.55; p=0.022).
conclusionsHigher baseline CRP levels were independently associated with non-response to the initial antibiotic regimen in patients with CAP.
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