ArticleCase reports in dentistry2026
Periodontal Nonsurgical Therapy With the Adjunctive Use of a Local Antibiotic for the Treatment of Deep Infrabony Defects in the Aesthetic Area: A Case Series.
Article in Case reports in dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background/Objectives: The presence of a vertical bone defect in an aesthetic area is common among many patients. The reduction of supracrestal soft tissue often occurs alongside the recession of interdental papillae, particularly following nonsurgical therapy. This case series study is aimed at presenting a clinical approach that combines ultrasound and localized antibiotics for managing deep infrabony defects in aesthetic zones. The goal is to achieve bleeding cessation and minimize recession prior to predictable regenerative periodontal surgery. Methods: Ten patients diagnosed with periodontitis: Each subject had at least one interproximal site in the aesthetic area presenting a PD value > 5 mm and BOP+ associated with a defect with radiographic infrabony component > 3 mm. FMPS, FMBS, PPD, REC, CAL, and BOP were performed at baseline and at 3 months. Conventional periodontal nonsurgical therapy was performed in all sites to achieve FMPS and FMBS values below 20%, whereas the infrabony defect site received a tailored treatment as follows: Ultrasonic tips were used incrementally (Tip A up to 4-mm subgingival, Tip P up to 7 mm, and Tip PS up to 11 mm) and a final application of 14% doxycycline-based antibiotic delivered by a controlled-release biodegradable vector. Results: All patients reported an improvement in PD values with no increase in REC and showed a negative BOP value. Mean PD decreased from 7.3 ± 1.9 mm to 5.2 ± 1.3 mm (mean reduction: 2.1 mm). Mean REC decreased from 0.9 ± 0.9 mm at baseline to 0.4 ± 0.5 mm at 3 months. BOP resolved in all treated sites (100%). No increase in REC was recorded in any patient. Conclusions: Nonsurgical therapy utilizing a minimally invasive approach with incremental ultrasonic tips and a local 14% doxycycline antibiotic seems capable of reducing inflammation parameters such as PPD and BOP without causing increased recession to enable predictable regenerative surgery.
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