ArticleFrontiers in neurology
Brain abscess in Honduras: a five-year clinical and epidemiological study at Hospital Escuela.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Brain abscess is a focal, life-threatening infection of the central nervous system associated with high morbidity and mortality, remaining scarcely studied in low-income settings. This study describes the clinical and epidemiological profile of patients with brain abscess at Hospital Escuela, Honduras (2018-2023), including treatment patterns and in-hospital outcomes. Methods: A retrospective descriptive case series was conducted at a tertiary referral hospital. Thirteen medical records were identified through ICD-10 coding (G06.0-G06.2). With diagnoses confirmed by radiological, microbiological, or documented clinical-team criteria. Analyzed variables included demographics, predisposing conditions, neuroanatomical location, number and estimated volume of abscesses, neuroimaging modality, microbiological findings, empirical and pathogen-directed antibiotic regimens, intensive care admission, and modified Rankin Scale at discharge. Descriptive statistics (frequencies and proportions with 95% confidence intervals by the Wilson method) were used. The study followed the STROBE reporting guidelines. Results: Of 13 patients, 61.5% were male, and 53.8% were pediatric (≤15 years; range 8-14 years). All abscesses were supratentorial (100%; 95% CI: 77.0-100.0%), with parietal and occipital lobes each affected in 30.8% of cases. Traumatic brain injury was the most frequent individual predisposing condition (23.1%; all three cases pediatric). Etiologic identification at any level was achieved in 30.8% of cases; direct microbiological confirmation from cerebrospinal fluid was available in one case. Identified organisms included Conclusion: This first institutional clinical-epidemiological characterization of brain abscess in Honduras demonstrates a pediatric-skewed cohort, a low etiologic identification rate, and a management pattern characterized by exclusive medical therapy. Survival was universal, but substantial neurological morbidity persisted at discharge. The findings should be interpreted as descriptive of a single national referral center and provide baseline data for future multicenter research in Central America.
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