Evidence map›Paper›PMID 42540343›Full record

ArticleJournal of oral microbiology2026

Buprenorphine enhances

Marlus S Pedrosa, Luca L Iannaccone, Charles S Schuls, Apoena A Ribeiro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marlus S PedrosaDepartment of Diagnostic Sciences (Cariology and Microbiology), Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID https://orcid.org/0000-0002-4052-7208
Luca L IannacconeCollege of Arts and Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID https://orcid.org/0009-0006-4003-5488
Charles S SchulsDepartment of Diagnostic Sciences (Cariology and Microbiology), Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID https://orcid.org/0009-0009-3797-6764
Apoena A RibeiroDepartment of Diagnostic Sciences (Cariology and Microbiology), Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID https://orcid.org/0000-0001-7702-6178

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Buprenorphine is widely prescribed for opioid use disorder (OUD). In 2022, the U.S. FDA issued a safety warning on dental diseases associated with buprenorphine. While reports implicate increased caries risk, the microbial mechanisms remain unclear. Objective: To evaluate whether buprenorphine directly modulates Design: Results: Buprenorphine did not affect planktonic growth, acid production, or carbohydrate metabolism. However, it increased biofilm biomass and EPS production. FISH imaging revealed denser matrix-rich biofilms with closer spatial integration of Conclusions: Buprenorphine promoted a biofilm-specific virulence program in

Indexed as

biofilmsBuprenorphinegenetic competenceoral healthStreptococcus mutans

Identifiers

PMID42540343
PMCPMC13425527

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.