Evaluating Alkaline Phosphatase-Instructed Self-Assembly of d‑Peptide Diesters for Selectively Inhibiting Immunosuppressive Cancer Cells.

Meihui Yi, Gabriel Ashton-Rickardt, Yuchen Qiao, Yali Huang, Hongjian He, Bing Xu

Abstract read

In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Meihui YiDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States.ORCID https://orcid.org/0000-0002-1912-1043

Gabriel Ashton-RickardtDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States.

Yuchen QiaoDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States.ORCID https://orcid.org/0009-0008-6401-6980

Yali HuangDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States.

Hongjian HeDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States.

Bing XuDepartment of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States.ORCID https://orcid.org/0000-0002-4639-387X

Funding

Subcellular Enzyme-instructed self-assembly for molecular anticancer nanomedicinesR01CA142746 · NCI · BRANDEIS UNIVERSITY · PI Bing Xu · 2010 to 2026

$6.4M

Selectively eliminating residual human induced pluripotent stem cells (iPSCs) in cell mixtures for cell therapyR21EY036512 · NEI · BRANDEIS UNIVERSITY · PI XU, BING · 2024 to 2025

$375k

NCI NIH HHS R01 CA142746NEI NIH HHS R21 EY036512

6 · The paper itself

Abstract

Hypoxia-driven adenosinergic signaling suppresses antitumor immunity and enables many tumors to evade cancer immunotherapy. Alkaline phosphatase (ALP) contributes to this immunosuppression by hydrolyzing extracellular adenosine triphosphate (ATP) to adenosine. Rather than inhibiting this broadly essential enzyme, we exploit elevated ALP activity in tumors as a tumor-specific trigger for enzyme-instructed self-assembly (EISA). Using a potent naphthalene-capped phosphopeptide diester precursor (

Identifiers

PMID42540203

DOI10.1021/acsomega.6c06074

PMCPMC13425513

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.