Evidence map›Paper›PMID 42540183›Full record

ReviewACS omega2026

Molecularly Imprinted Polymers as Interceptors of Bacterial Quorum Sensing: Design Principles, Translational Challenges, and Therapeutic Applications.

Tama S Mwale, Gillian D Mahumane, Khonzisizwe Somandi, Monika Sobiech, Sandy van Vuuren, Piotr Luliński, Yahya E Choonara

Abstract readReview
In one paragraph

Review in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tama S MwaleWits Advanced Drug Delivery Platform Research Unit, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg, Gauteng 2193, South Africa.
Gillian D MahumaneWits Advanced Drug Delivery Platform Research Unit, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg, Gauteng 2193, South Africa.
Khonzisizwe SomandiWits Advanced Drug Delivery Platform Research Unit, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg, Gauteng 2193, South Africa.
Monika SobiechDepartment of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, Warsaw 02-097, Poland.ORCID https://orcid.org/0000-0002-5687-2874
Sandy van VuurenDepartment of Pharmacy and Pharmacology, School of Therapeutic Science, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg, Gauteng 2193, South Africa.
Piotr LulińskiDepartment of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, Warsaw 02-097, Poland.ORCID https://orcid.org/0000-0001-8421-5225
Yahya E ChoonaraWits Advanced Drug Delivery Platform Research Unit, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg, Gauteng 2193, South Africa.ORCID https://orcid.org/0000-0002-3889-1529

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quorum sensing (QS) orchestrates virulence, biofilm maturation, and antimicrobial tolerance across clinically dominant pathogens, driving chronic infections and therapeutic failure. Although quorum-sensing inhibitors (QSIs) were developed to attenuate pathogenic coordination without bactericidal pressure, their clinical translation has been constrained by biochemical instability, narrow receptor specificity, limited pharmacokinetic robustness, and emerging adaptive resistance. Molecularly imprinted polymers (MIPs) provide a mechanistically distinct strategy based on structurally defined recognition cavities capable of physically sequestering or catalytically degrading autoinducers with measurable thermodynamic parameters, including the imprinting factor (IF), dissociation constant (

Identifiers

PMID42540183
PMCPMC13425475

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.