ReviewACS omega2026
Ireland-Claisen Rearrangement as a Stereocontrolled Bond-Construction Strategy in Natural Product Total Synthesis.
Review in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
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Abstract
Among stereoselective C-C bond-forming transformations in organic synthesis, the Ireland-Claisen rearrangement plays a distinct role as a reliable method for the construction of stereogenic centers and geometrically defined double bonds. Its synthetic value arises from the efficient transfer of stereochemical information through a highly ordered six-membered transition state, enabling rapid increases in molecular complexity under mild reaction conditions. This review highlights recent applications of the Ireland-Claisen rearrangement in natural product total synthesis, covering literature published during 2015-2025. The examples discussed demonstrate the broad utility of this transformation across structurally diverse natural product classes and illustrate how substrate structure, enolization conditions, and reaction design determine the stereochemical outcome in complex synthetic settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.