Evidence map›Paper›PMID 42540126›Full record

ArticleACS omega2026

The 5'-Isobutyryl Ester Prodrug of 4'-Thiouridine Inhibits SARS-CoV‑2 Replication in Culture and in a Syrian Hamster Infection Model.

Zhe Chen, Franck Amblard, Mahesh Kasthuri, Zahira Tber, Julia C LeCher, Sijia Tao, Ramyani De, Ingrid Marko, Leda Bassit, Keivan Zandi and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Zhe ChenCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia 30322, United States.
Franck AmblardCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia 30322, United States.ORCID https://orcid.org/0009-0002-6235-4050
Mahesh KasthuriCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia 30322, United States.
Zahira TberCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia 30322, United States.
Julia C LeCherCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia 30322, United States.
Sijia TaoCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia 30322, United States.
Ramyani DeCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia 30322, United States.
Ingrid MarkoDepartment of Molecular Biosciences, University of Texas at Austin, Austin, Texas 78712, United States.
Leda BassitCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia 30322, United States.
Keivan ZandiCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia 30322, United States.
Tamara McBrayerCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia 30322, United States.
Selwyn H HurwitzCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia 30322, United States.
Birgit WeynandDepartment of Imaging and Pathology, Translational Cell and Tissue Research, Division of Translational Cell and Tissue Research, KU Leuven, Leuven 3000, Belgium.
Rana AbdelnabiDepartment of Microbiology, Immunology and Transplantation, Rega Institute, Virology, Antiviral Drug & Vaccine Research Group, KU Leuven, Leuven 3000, Belgium.
Johan NeytsDepartment of Microbiology, Immunology and Transplantation, Rega Institute, Virology, Antiviral Drug & Vaccine Research Group, KU Leuven, Leuven 3000, Belgium.
Siddhartha BhattResearch and Development, Pfizer, Groton, Connecticut 06340, United States.
Britton BorasResearch and Development, Pfizer, La Jolla, California 92121, United States.ORCID https://orcid.org/0000-0003-3624-9177
Rhonda D CardinResearch and Development, Pfizer, Pearl River, New York 10965, United States.
Yuao ZhuResearch and Development, Pfizer, Pearl River, New York 10965, United States.
Mili KapoorResearch and Development, Pfizer, Pearl River, New York 10965, United States.
Heather EngResearch and Development, Pfizer, Groton, Connecticut 06340, United States.
Amit S KalgutkarResearch and Development, Pfizer, Cambridge, Massachusetts 02139, United States.ORCID https://orcid.org/0000-0001-9701-756X
Siennah R GreenfieldResearch and Development, Pfizer, Cambridge, Massachusetts 02139, United States.
Rhishikesh ThakareResearch and Development, Pfizer, Cambridge, Massachusetts 02139, United States.
Amanda King-AhmadResearch and Development, Pfizer, Groton, Connecticut 06340, United States.
Nandini C PatelResearch and Development, Pfizer, Cambridge, Massachusetts 02139, United States.
Kenneth A JohnsonDepartment of Molecular Biosciences, University of Texas at Austin, Austin, Texas 78712, United States.
David HepworthResearch and Development, Pfizer, Cambridge, Massachusetts 02139, United States.
Andrew FensomeResearch and Development, Pfizer, Cambridge, Massachusetts 02139, United States.ORCID https://orcid.org/0000-0001-8916-1895
Raymond F SchinaziCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia 30322, United States.ORCID https://orcid.org/0000-0002-6688-3614

Funding

Dynamics of Hepatis C viral RNA-dependent RNA replicationR01AI110577 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI JOHNSON, KENNETH ALLEN · 2015 to 2018
$1.8M
NIAID NIH HHS R01 AI110577
6 · The paper itself

Abstract

Although the SARS-CoV-2 pandemic is now largely controlled through widespread vaccination and available therapeutics, emerging variants could undermine their overall effectiveness. 4'-Thiouridine (

Identifiers

PMID42540126
PMCPMC13425281

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.