ArticleOpen medicine (Warsaw, Poland)2026
TP63 regulates pyroptosis via NF-κB/NLRP3/caspase-1 signaling in interstitial cystitis: insights from single-cell sequencing.
Article in Open medicine (Warsaw, Poland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: This study aims to explore the regulatory role of the TP63 gene in interstitial cystitis (IC) and its molecular mechanism of involvement in disease occurrence and development through the pyroptosis pathway through single-cell sequencing and bioinformatics analysis, and evaluate its potential as a therapeutic target and biomarker. Methods: A 6-8 week SPF grade female SD rat IC model was constructed by intraperitoneal injection of cyclophosphamide (n=10/group, repeated 3 times). The model construction effect was verified by the Von Frey fiber tenderness method, urodynamic evaluation, and bladder histopathological analysis. Screening key genes related to apoptosis in bladder tissue of IC rats using single-cell sequencing and bioinformatics analysis. Results: Single-cell sequencing and bioinformatics analysis showed that the TP63 gene was significantly upregulated in the bladder tissue of IC rats (p<0.0001). Western blotting results showed a significant increase in the expression of apoptosis-related proteins in the IC model (p<0.0001), while HE staining showed a significant increase in the infiltration of mast cells, macrophages, and T cells (p<0.05). Conclusions: TP63 contributes to the pathogenesis of IC by directly binding to the RELA promoter, activating NF-κB signaling, and subsequently regulating the NLRP3/caspase-1/GSDMD axis to induce bladder epithelial cell pyroptosis. TP63 shows promise as a potential biomarker and therapeutic target for IC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.