ArticleSkin health and disease2026
A new association of cutaneous leishmaniasis with guselkumab in a patient with chronic psoriasis.
Article in Skin health and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A 68-year-old White man presented with a 3-month history of two nontender, pruritic, erythematous plaques on his left arm. He had a medical history of chronic plaque psoriasis that has been stable on guselkumab treatment, an anti-interleukin-23 monoclonal antibody, for 5 years. The lesions persisted, despite topical treatments. His medical history also included previous cutaneous squamous cell carcinoma, recurrent penile Bowen disease and psoriasis that responded inadequately to -multiple biologics before the initiation of guselkumab. A biopsy of a persistent lesion was carried out, which confirmed the diagnosis of cutaneous leishmaniasis. Histopathology demonstrated extensive alignment of amastigotes along the peripheries of histocytes, a pathognomonic sign known as the 'marquee sign'. Physical examinations and serology were unremarkable. Polymerase chain reaction of the tissue biopsy identified possible involvement of
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