ReviewSkin health and disease2026
Systemic associations of pyoderma gangrenosum: a systematic review.
Review in Skin health and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that may be associated with systemic diseases. Characterizing these associations is clinically relevant for diagnosis, prognosis and management. Objectives: To systematically review acquired systemic diseases associated with PG in adults and describe related clinical features and treatment approaches. Methods: We searched PubMed/MEDLINE, Embase and Scopus from January 2015 to May 2025. Eligible studies included observational studies, case reports and case series reporting systemic associations of PG in adults. Data extraction was performed independently by two reviewers and the risk of bias was assessed using the Joanna Briggs Institute checklists. Results: Nineteen observational studies and 18 case-based studies were included. The most frequent systemic associations were inflammatory bowel disease ( Conclusions: PG demonstrates diverse systemic associations, ranging from well-established links to rarer conditions. Observational studies strengthen evidence for common associations, while case-based literature provides insights into clinical patterns and emerging therapies. Larger prospective studies are needed to clarify causality and optimize management.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.