Evidence map›Paper›PMID 42540028›Full record

ArticleSports medicine and health science2026

"CLINICAL-BFR": An exploratory blood flow restriction protocol focusing on clinical application.

Fabricio Eduardo Rossi, Kassiana de Araújo Pessôa, Zhi Xia, Jakob Lauver, Daniel Newmire, Jason Michael Cholewa, Steven Machek, Mario Alves de Siqueira Filho, Fabio Santos Lira, Antonio Herbert Lancha-Jr and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sports medicine and health science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fabricio Eduardo RossiImmunometabolism of Skeletal Muscle and Exercise Research Group, Department of Physical Education, School of Technology and Sciences, São Paulo State University (UNESP), Presidente Prudente, SP, Brazil.
Kassiana de Araújo PessôaLaboratory of Skeletal Muscle Biology and Human Strength Performance (LABFORCEH), Federal University of Maranhão (UFMA), São Luís, MA, Brazil.
Zhi XiaExercise Physiology and Biochemistry Laboratory, College of Physical Education and Health, Wenzhou University, Wenzhou, China.
Jakob LauverDepartment of Kinesiology, Coastal Carolina University, Conway, SC, USA.
Daniel NewmireSchool of Health Promotion and Kinesiology, Texas Woman's University, Denton, TX, USA.
Jason Michael CholewaDepartment of Exercise Physiology, College of Health Sciences, University of Lynchburg, USA.
Steven MachekKinesiology Department, College of Health Sciences and Human Services, California State University - Monterey Bay, Seaside, CA, USA.
Mario Alves de Siqueira FilhoDepartment of Physical Education, Federal University of Maranhão (UFMA), São Luís, MA, Brazil.
Fabio Santos LiraExercise and Immunometabolism Research Group, Department of Physical Education, School of Technology and Sciences, São Paulo State University (UNESP), Presidente Prudente, SP, Brazil.
Antonio Herbert Lancha-JrLaboratory of clinical investigation: experimental surgery, LIM26, Hospital das Clínicas, Faculdade de Medicina, University of São Paulo, Brazil.
Emilia ZawiejaDepartment of Human Nutrition and Dietetics, Poznan University of Life Sciences, Poland.
Nelo Eidy ZanchiLaboratory of Skeletal Muscle Biology and Human Strength Performance (LABFORCEH), Federal University of Maranhão (UFMA), São Luís, MA, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Traditional blood flow restriction resistance training (BFR-Trad) is a cost-effective and time-efficient exercise modality that offers significant skeletal muscle benefits, including strength and mass gains. Despite employing low loads, BFR-Trad may not be well tolerated by all populations due to its high intensity, pain-associated muscle discomfort, low affectivity, and cardiovascular responses. Consequently, reducing BFR intensity may be an interesting approach to making traditional BFR more clinically applicable. This was approached through the proposal of the present Clinical BFR. Methods: Twenty-two healthy, untrained subjects (both female and male) aged between 18 and 30 years participated. Subjects completed three sessions of unilateral knee extension exercises randomly assigned to the BFR-Trad, BFR-Clinical_c (cadenced), and BFR-Clinical_a (-autoregulated) exercise protocols. Results: The BFR-Trad condition induced greater increases in perceived exertion, discomfort, delayed onset muscle soreness (DOMS), and lactate levels compared to the BFR-Clinical conditions ( Conclusion: Compared to traditional BFR, clinical BFR was scored as less intense, reduced pain-associated discomfort, decreased DOMS, increased affectivity, diminished systolic blood pressure responses, decreased fatigue and muscle activation, and promoted similar glycemic responses. Altogether, our results support the potential use of clinical BFR in clinical settings.

Indexed as

Blood flow restrictionDiscomfortMuscle fatigueMuscle powerResistance training

Identifiers

PMID42540028
PMCPMC13424933

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.