Evidence map›Paper›PMID 42539873›Full record

ArticleFrontiers in cellular neuroscience2026

Single-nucleus transcriptomics identifies cell cycle and synaptic pathway dysregulation during OPC-to-glioma progression.

Dennis Huang, Angeliki Mela, Hye-Jin Park, Peter Canoll, Patrizia Casaccia

Abstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dennis HuangProgram in Molecular, Cellular and Developmental Biology at The Graduate Center of The City University of New, New York, NY, United States.
Angeliki MelaDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, United States.
Hye-Jin ParkNeuroscience Initiative, Advance Science Research Center, Graduate Center of The City University of New York, New York, NY, United States.
Peter CanollDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, United States.
Patrizia CasacciaProgram in Molecular, Cellular and Developmental Biology at The Graduate Center of The City University of New, New York, NY, United States.

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Environmental Biosensors in the Oligodendrocyte LineageR35NS111604 · NINDS · ADVANCED SCIENCE RESEARCH CENTER · PI Patrizia Casaccia · 2019 to 2026
$9.1M
Outreach CoreU54CA274504 · NCI · MAYO CLINIC ARIZONA · PI Kristin R Swanson · 2023 to 2026
$8.6M
Single Cell Analysis of the Infiltrative Margins of Glioblastoma and Post Treatment RecurrenceR01NS103473 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JEFFREY N BRUCE, Peter Canoll · 2017 to 2026
$4.3M
NCI NIH HHS P30 CA013696NCI NIH HHS U54 CA274504NINDS NIH HHS R01 NS103473NINDS NIH HHS R35 NS111604
6 · The paper itself

Abstract

Gliomas are characterized by poor survival rate and limited options for treatment. Based on the transcriptional enrichment for oligodendrocyte progenitor cell (OPC) transcripts, the proneural glioma is thought to arise from transformation of OPCs. Here, we injected mutant BB-p53n OPCs (with

Indexed as

brain tumorglianeuronp53PDGFprogenitortranscription

Identifiers

PMID42539873
PMCPMC13424661

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.