Evidence map›Paper›PMID 42539806›Full record

ReviewFundamental research2026

Molecular identity of the mechanotransduction machinery in inner ear hair cells and mechanotransduction-linked hearing loss.

Yanyan Jia, Huawei Li, Wenyan Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Fundamental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yanyan JiaENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China.
Huawei LiENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China.
Wenyan LiENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hearing is among the most sensitive sensory modalities in vertebrates, and its dysfunction can lead to hearing loss. Auditory perception within the inner ear relies on mechanosensitive hair cells and a sophisticated network of molecules that comprise the machinery responsible for mechanotransduction. The mechanosensory hair cells exhibit distinct structural features that enable them to transform sound vibrations into electrical signals, which are then relayed to the spiral ganglion neurons (SGNs) that are connecting between the cochlear hair cells and the cochlear nuclei with high accuracy and fidelity. Despite over 40 years of research, the precise molecular composition and assembly of the mechanotransduction channel complex within cochlear hair cells remains elusive. This review presents recent findings that provide new perspectives on the molecular components and assembly of the mechanotransduction apparatus in cochlear hair cells, as well as genetic mutations related to mechanotransduction dysfunction and hearing loss.

Indexed as

Auditory hair cellHearing lossMechano-electrical transduction (MET)MET channel complexTMC1 channel

Identifiers

PMID42539806
PMCPMC13424396

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.