Bacterial pathogens and antimicrobial susceptibility profiles in acute appendicitis in children: a retrospective study at a tertiary hospital in Ningbo, China.

Jingjuan Chen, Wenyuan Liu, Yibo Chen, Wenbo Lu, Yunlong Liu, Yefang Ke

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Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Jingjuan ChenDepartment of Clinical Laboratory, Women and Children's Hospital of Ningbo University, Ningbo, Zhejiang, China.

Wenyuan LiuDepartment of Clinical Laboratory, Women and Children's Hospital of Ningbo University, Ningbo, Zhejiang, China.

Yibo ChenDepartment of Clinical Laboratory, Women and Children's Hospital of Ningbo University, Ningbo, Zhejiang, China.

Wenbo LuDepartment of Clinical Laboratory, Women and Children's Hospital of Ningbo University, Ningbo, Zhejiang, China.

Yunlong LiuDepartment of Pediatric Surgery, Women and Children's Hospital of Ningbo University, Ningbo, Zhejiang, China.

Yefang KeDepartment of Clinical Laboratory, Women and Children's Hospital of Ningbo University, Ningbo, Zhejiang, China.

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6 · The paper itself

Abstract

Objective: To investigate the distribution of bacterial pathogens in intraoperative specimens from children with acute appendicitis, characterize the antimicrobial resistance profiles of predominant Gram-negative bacteria, and compare microbiological differences between non-gangrenous and gangrenous appendicitis. Methods: We retrospectively reviewed records of patients aged below 18 years who underwent appendectomy for pathologically confirmed acute appendicitis at a tertiary hospital in Ningbo, China, between January 2019 and December 2024. Intraoperative pus, peritoneal fluid, or drainage fluid was cultured aerobically, and isolates were identified and tested for antimicrobial susceptibility. Pathology-stratified analyses compared infection type and major pathogen detection between non-gangrenous and gangrenous appendicitis. Results: Among 1,981 children, 1,393 (70.31%) had positive cultures, yielding 1,903 isolates. Gram-negative organisms accounted for 81.14%. The three most common Gram-negative pathogens were Conclusion: In Ningbo,

Indexed as

acute appendicitisantimicrobial resistancebacteriachildrenintraoperative specimens

Identifiers

PMID42539771

DOI10.3389/fped.2026.1871617

PMCPMC13424214

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