Fine-tuning of the CRWN2-NTL9 module to repress PR1 expression by a viral effector during geminivirus infection.

Chenlu Su, Yaqin Wang, Fangfang Li, Yuzhen Mei, Xueping Zhou

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Article in Fundamental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Chenlu SuState Key Laboratory of Rice Biology and Breeding, Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China.

Yaqin WangState Key Laboratory of Rice Biology and Breeding, Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China.

Fangfang LiState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Yuzhen MeiState Key Laboratory of Rice Biology and Breeding, Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China.

Xueping ZhouState Key Laboratory of Rice Biology and Breeding, Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CROWDED NUCLEIs (CRWNs) are nuclear lamina proteins that play an important role in plant immunity. Nevertheless, the molecular mechanism of how CRWNs regulate host immunity and the mechanism by which pathogens manipulate CRWN-mediated immunity regulation is not understood. In this study, we report that CRWN2 negatively regulates anti-geminiviral defense responses through enhancing the function of NAC with transmembrane motif 1-like 9 (NTL9), and the CRWN2-NTL9 module attenuating host defenses is exploited by the geminivirus tomato yellow leaf curl China virus (TYLCCNV). CRWN2 directly interacts with the transcription factor NTL9 and enhances its binding activity on the promoter of the pathogenesis-related gene

Indexed as

Crowded nucleiGeminivirusNTL9Plant immunityV2 protein

Identifiers

PMID42539757

DOI10.1016/j.fmre.2025.06.003

PMCPMC13424409

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